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Wednesday, June 12, 2024


Dextroamphetamine, often known by its brand name “Dexedrine”, is an addictive prescription stimulant that has medical use in treating hyperactivity disorders such as ADHD as well as narcolepsy. Dexedrine abuse is relatively less common than other drugs of its kind, but is still regularly abused in the U.S and abroad due to the increasing frequency of ADHD diagnoses each year, with there being a 50% increase in the use of these drugs in a matter of six years.1 Dexedrine is so addictive due to its close interaction with dopamine production in the brain. Dexedrine remains one of the more popular recreational drugs found today due to its ability to increase focus and energy when abused, and commonly develops into an addiction due to how easy it is to build a tolerance to it. While overdoses are relatively uncommon on Dexedrine, death can occur from a variety of issues such as respiratory failure and cardiac problems well below the quantity usually considered high enough to overdose. Dexedrine exhibits short-term effects similar to other prescription stimulants including alertness, euphoria, decreased appetite, and mood shifts. Long term abuse of Dexedrine can lead to a variety of physiological and mental ailments including depression, skin deterioration, cardiovascular problems, and Raynaud’s phenomenon. While there are no drugs specifically for Dexedrine addiction, there are currently many effective pharmaceutical drugs that can be used in treatment of Dexedrine addiction, and rehabilitation facilities offer extensive resources for recovering from Ritalin addiction in a safe, stable, and comfortable manner.

What is Dexedrine?

Dexedrine is a relatively less common stimulant drug available for the treatment of conditions such as ADHD and narcolepsy than other drugs of its class such as Adderall and Ritalin, but has just as common a history of abuse. Dexedrine holds a reputation for its long lasting feelings of energy and euphoria, its potent addictiveness, and its usage in the certain conditions in the military. Stimulants are a class of drugs that include dangerous street drugs like cocaine, common prescription drugs such as Ritalin, and even your ordinary cup of coffee. Dextroamphetamine is a specific central nervous system stimulant that is chemically related to drugs such as methamphetamine, and is notable for its potent stimulating effects as well as its strong addictiveness. Dexedrine along with Adderall is generally considered to be one of the strongest in its class, and is generally used when less potent drugs such as Ritalin have shown to be ineffective. Dextroamphetamine has been in regular use since the turn of the 20th century, and had popular usage in the U.S. military starting in WWII. Members of the U.S. Army often took pills which consisted of uncut Dextroamphetamine, and is still used today as a stimulant for particularly fatigued conditions such as long range bombing missions. Usage of Dexedrine has been steadily and quickly increasing as the drug becomes more popular, particularly in college-aged groups due to Dexedrine’s use as a study aid. This trend is troubling, as Dexedrine usage has shown significant increase in the likelihood of using other drugs such as cocaine, and participating in dangerous habits like binge drinking. While it is somewhat difficult to overdose on Dexedrine, death can still occur on Dexedrine significantly below the amount required to overdose due to Dextroamphetamine’s strong effect on the heart. Cardiac arrest, heart attack, and other heart-related conditions can occur on any amount of Dexedrine, with the risk increasing with the dose and in those with pre-existing heart conditions.

How Does Dexedrine Addiction Work?

Dexedrine’s deadly addictiveness can be attributed primarily to its effectiveness as a central nervous system stimulant, which stimulates dopamine production in the brain. This forces the dopamine out of the cell, trapping it in the synapse and leading to severe overstimulation of dopamine receptors in the brain. Dopamine is a neurotransmitter that is colloquially known as the ‘happiness drug’ due to its purpose in producing feelings of well-being and pleasure when released into the brain. When the body is hurt, the brain produces natural opiates that allow dopamine to be released in the areas of the brain commonly responsible for feelings of pain and stress, which works to reduce overall feelings of pain. However, once dopamine has done its job, it must be taken back out of the synapse to avoid overstimulating the cell. Dexedrine disables this preventative measure in the brain by taking the place of dopamine. Because the brain isn’t capable of handling such frequent binding of dopamine, dopamine receptors become damaged and make it more difficult to feel pleasure, leading users to use more and more Dexedrine to chase the fleeting euphoria it once offered them. Dexedrine is particular addictive because, once ingested, it concentrates in the area of the brain known as the reward pathway. These numerous issues compound to create a very strong addiction potential for Dexedrine, which becomes more and more difficult to feed the more it is abused. This deadly self-feeding cycle of addiction is at the root of Dexedrine’s effectiveness at becoming addictive.

Short and Long Term Effects

Dexedrine is usually taken in the form of compressed tablets, but is also sometimes used recreationally by crushing it into a powder and snorting it. Onset of effects varies with the method used to take it, but Dexedrine generally takes effect between 30-60 minutes after ingestion.

Users report short-term mental effects such as feelings of:

    • Increased energy
    • Increased alertness
    • Euphoria
    • Sexual stimulation
    • Excessive talking
    • Increased motivation
    • Aggressiveness
    • Paranoia
    • Rapid mood shifts

And physical effects such as:

    • Dizziness
    • Numbness
    • Excessive sweating
    • Severe dryness of the mouth
    • Insomnia
    • Restlessness

Repeated long-term use of Dexedrine leads to physical side effects such as:

    • Decay in skin health – Regular usage of Dexedrine has been linked to a variety of skin conditions including those associated with both excessively oily and excessively dry skin. Dexedrine has been linked with a significant increase in acne, as well as dry, irritated, and itchy skin with chronic use.
    • Anorexia – Because of Dexedrine’s effect of appetite suppression, Dexedrine has been linked to unhealthy weight loss. This can result in anorexia, as well as a host of illnesses and conditions brought about from malnutrition including muscle atrophy and immune disorders.
    • Respiratory damage – Chronic Dexedrine usage has been shown to begin and cause a number of respiratory issues. This can include respiratory depression, irregular breathing, and chronic shortness of breath.
    • Insomnia – Due to Dexedrine’s stimulating effect, a general decay in personal health, as well as frequent interruptions in ordinary circadian activity, Dexedrine users often experience worsening sleeping problems that can develop into insomnia.

Long-term use of Dexedrine also carries several mental side effects including:

    • Severe addiction – Because of Dexedrine’s addictiveness, both mental and physical addiction are developed very quickly, leading to a complete dependency on the drug.
    • Depression – Due to overstimulation of dopamine receptors, Dexedrine frequently leads to depression due to the brain’s inability to properly manage its circadian rhythm and dopamine production.
    • Anxiety – Anxiety is a frequent symptom of drug abuse in general, and is common in Dexedrine abuse due to internal factors from the psychological and physical effect of the drug itself, as well as external factors such as pressure family, friends, and work that may all be affected by addiction. This can compound and develop into chronic paranoia.

Other risks posed by Dexedrine abuse include:

    • Raynaud’s phenomenon – A condition that has been associated with Dexedrine usage specifically is Raynaud’s phenomenon. This condition is accompanied by reduce sensitivity in the extremities, feelings of numbness and coldness, and changes in skin color, usually around the fingers.
    • Risk of overdose – Dexedrine overdose is a sometimes understated but dangerously frequent occurrence. Because Dexedrine tolerance is so volatile, and deadly effects can take place well under the accepted limit that can be taken, Dexedrine has caused a significant number of deaths from taking doses too high or too often. Death by heart failure is common, and survival rates of overdoses are low.

Dexedrine withdrawal is notoriously difficult to go through, and includes symptoms such as:

    • Psychosis
    • Fatigue
    • Respiratory failure
    • Fever
    • Anxiety
    • Depression
    • Heart palpitations
    • Tremors, muscle aches and cramps
    • Insomnia

Methods of Treatment


There are a large number of drugs that can be used for Dexedrine addiction and the drug or drugs used depend upon the circumstances of the addiction and the condition of the patient. Some drugs such as baclofen, a GABA antagonist, work by reducing Dexedrine’s effect on the dopamine reward pathway in the brain. By lessening this effect, baclofen is able to dissociate the drug from its associated feeling of pleasure. Other drugs such hydroxyzine work by reducing the negative effects of withdrawal, allowing the patient to go through detox and likely rehabilitation while minimizing the difficulty of no longer using the drug. This helps not only to reduce the pain of withdrawal, but makes it easier to maintain sobriety afterward as well. Drugs such desipramine, a tricyclic antidepressant, can increase the quantity of norepinephrine in the brain, allowing it to replenish naturally and maintain abstinence. This drug may be particularly useful for drugs like Dexedrine because despiramine has been used in the treatment of ADHD, and may be able to treat or reduce the effects of hyperactivity disorders that may have led to the use of Dexedrine in the first place.


Other forms of treatment for Dexedrine addiction come in the form of psychological and behavioral therapies. These treatments focus on the behaviors and habits that led to addiction in the first place in an attempt to remove the root of addiction. Amongst these forms of treatment, Cognitive Behavioral Therapy (CBT) is one of the most common, and is growing in support from the scientific and clinical communities all the time. Cognitive Behavioral Therapy sees substance abuse such as Dexedrine addiction as a symptom of a greater psychological issue, and not a cause in and of itself. By utilizing reflective and analytic techniques, an addict is better able to understand what led them to addiction in the first place, change bad habits, and avoid behaviors that may trigger cravings. The twelve-step program, which is utilized by Alcoholic Anonymous, is a long-established method of treating drug and alcohol addiction. The twelve-step program works as a gradual method of guiding principles and pragmatic steps that can be taken to go from the depths of addiction and unhealthy habits to sobriety. These twelve steps are aimed at effectively recovering from compulsive and addictive behaviors, and addressing mental and behavioral problems that led to addiction in the first place. These twelve steps include both internal and external actions aimed at making amends for past mistakes, accepting responsibility for the actions that led to addiction, and moving forward to establish healthy habits and a positive mindset.


There are two main types of rehabilitation: inpatient and outpatient. Inpatient rehabilitation refers to programs that require patients to check themselves into a facility where they will undergo all rehabilitation treatment. Although inpatient rehabilitation requires a greater level of commitment, the facilities, environment, and support offered by these facilities are conducive to a stable and effective recovery. Inpatient facilities generally offer services such as psychiatrists, counselors, group therapy, and all of the living facilities necessary for a comfortable stay. The extensive support offered by these facilities, combined with an environment that is focused on self-improvement and wellness is a great combination for providing the motivation to push through the difficulties of withdrawal and to establish good healthy habits to prevent relapsing once you leave. This form of rehabilitation is effective for those who would benefit from a stricter more scheduled recovery in which the outside distractions and temptations of life won’t get in the way of focusing on recovery.

Outpatient rehabilitation is based on the principle of spending only part of your time in recovery programs while offering you the freedom to continue daily living on your own. Generally these programs will require ten to twelve hours of commitment per week spent in a treatment facility participating in similar activities to those done in an inpatient facility such as group therapy, counseling, and even detox. While this does offer easier access to drugs, some may find being able to maintain their normal daily schedule more beneficial. This form of rehabilitation is effective for those who require more freedom and contact with friends and family.

Both forms of rehabilitation are effective solutions at combatting Dexedrine addiction, and there is a variety of different types of both inpatient and outpatient rehabilitation to suit the personal needs of each individual.


    1. BBC Health. “Use of ADHD Drugs ‘Increases by 50% in Six Years’.” BBC News, BBC, 13 Aug. 2013, www.bbc.com/news/health-23674235.